Our viruses can be used alone or in conjunction with other family of oncolytic viruses for cancer treatment.
Originally isolated from a healthy child, and found to cause no diseases in nature. Patients in clinical trials exhibited only mild, flu-like symptoms. Pre-clinical studies found a strong angiogenesis inhibition in animal models.
A naturally occurring rabbit-specific pox virus, found to cause no diseases outside rabbit species in nature. In pre-clinical studies, shown to be highly oncolytic against tumor-bearing animals.
A naturally occurring squirrel-specific pox virus, found to cause no diseases outside of squirrel species in nature. In pre-clinical studies, shown to be highly oncolytic against tumor-bearing animals.
Mechanistic basis of a replicating viral oncotropism against various malignancies
Carcinogenesis is a multi-step process involving accumulation of cellular oncogenes and tumor suppressor gene abnormalities both genetically and/or functionally.
In the case of normal cells, DNA damages (externally or internally) could be repaired by normal checkpoint activities such as cell cycle arrest or apoptosis restricting viral propagation due to preservation of anti-viral integrity. However, tumor suppressor defective cancers couldn't handle genotoxic challenges, resulting in genomic instability and defective checkpoints/antiviral responses.
Taken together, abnormal cells can be preferentially infected by replicating viruses due to loss of intact anti-viral functionality.